How To Make Sure Dmg Is Safe

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bigmillz

Senior Member

I've been using TMG for a while, and wondering if it's starting to lower my energy levels a bit. This had happened last year, per my log. I'd like to try DMG, based on reading what Rich said about long term use of TMG being problematic for some:

'The betaine will stimulate the alternative BHMT pathway in the liver and kidneys, and that may make it difficult to lift the partial block in the methionine synthase pathway, which is linked to the folate metabolism, and which needs to be operating normally to bring glutathione up and also get the folate metabolism back to normal. So if you don't notice much change after being on the simplified treatment approach for a couple of months or so, then you could consider adding some DMG (dimethylglycine), which will slow down the BHMT pathway and hopefully shift more of the flow to the methionine synthase pathway. I think this has to be done by trial and error, because different people may respond differently, based on genetics.'

However, I found this while searching around:

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Dimethylglycine (DMG) and trimethylglycine (TMG) donate methyl groups to the methylation cycle. TMG is needed to recycle homocysteine and help produce SAMe. If DMG is beneficial for your child, note that long term use will slow methylation. After a period of DMG supplementation, it is important to start using TMG and SAMe to optimize this vital cycle needed for neurological health.

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Source: http://treatautism.ca/2015/03/31/au..ping-to-repair-your-childs-methylation-cycle/
Not sure I trust this site. Most everything I've read here shows that DMG can be considered after TMG to move away from the BHMT pathway, once the 'long route' is well supported.

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Thoughts on this? Has anyone moved from TMG to DMG and had positive results?